from 10-K 63 pages Pharmaceutical Product Supply Agreement Dated January 27, 2005 by and Between Dsm Pharmaceuticals, Inc. and Barrier Therapeutics, Inc

from 10-K 28 pages Manufacturing Agreement Dpt Laboratories, Ltd. and Barrier Therapeutics, Inc

from 10-K 4 pages Re: Amendment No. 1 (This “Amendment”) to the Pharmaceutical Product Supply Agreement Dated January 27, 2005 (The “Agreement”) by and Between Dsm Pharmaceuticals, Inc. (“Dsm”) and Barrier Therapeutics, Inc. (“Barrier”) Dear Mr. Rizzo: This Letter Confirms the Recent Discussions Between Dsm and Barrier Regarding the Proposed Amendment of the Pharmaceutical Product Supply Agreement (The “Agreement”) Referenced Above. All Terms and Conditions Defined Herein Are Used as Defined in the Agreement. This Amendment No. 1 Amends the Specific Terms Referenced Below. 1. Exhibit 1 of Agreement Shall Be Revised to Reflect Changes to the 2005 and 2006 Minimum Quantities and the Product Price for Each Contract Year. the Revised Exhibit 1 Is Attached Hereto and Incorporated Herein by Reference. 2. Section 2.2 of the Agreement Shall Be Amended to Read as Follows

from 10-K 13 pages Amended and Restated Employment Agreement

from 10-K 13 pages Amended and Restated Employment Agreement

from 10-K 13 pages Amended and Restated Employment Agreement

from 10-K 13 pages Amended and Restated Employment Agreement

from 10-K 13 pages Amended and Restated Employment Agreement

from 10-K 12 pages Sales Force Services Agreement

from 10-K 1 page List of Subsidiaries

from 10-K 1 page Consent of expert or counsel

from 10-K 1 page Management certification of annual or quarterly disclosure

from 10-K 1 page Management certification of annual or quarterly disclosure

from 10-K 1 page Management certification of annual or quarterly disclosure

from 10-K 1 page Management certification of financial report

from 10-K 1 page Management certification of financial report

from 10-K 1 page Management certification of financial report

from 10-K g44942g21w73.jpg