Opko Health Inc. Watch

from SC 13D/A ~5 pages Underwriting agreement

from 8-K ~50 pages Underwriting Agreement

from SC 13G/A 1 page Bristol-Myers Squibb Pharma Company (Formerly Dupont Pharmaceuticals Company), a Delaware General Partnership and Wholly-Owned Subsidiary of Bristol-Myers Squibb Company, Acquired the Securities Being Reported on in This Schedule 13g/a Upon the Consummation of the Acquisition of Dupont Pharmaceuticals Company by Bristol-Myers Squibb Company on October 1, 2001. the Sole Partners of Bristol-Myers Squibb Pharma Company Are Bristol-Myers Squibb Pharma Holding Company, L.L.C. and E. R. Squibb & Sons, L.L.C. E. R. Squibb & Sons, L.L.C. Owns All of the Outstanding Stock of Bristol-Myers Squibb Pharma Holding Company, L.L.C. Bristol-Myers Squibb Company Owns All of the Outstanding Stock of E. R. Squibb & Sons, L.L.C

from SC 13G 1 page <page> 1 Exhibit 1 Dupont Pharmaceuticals Company, a Delaware General Partnership and a Wholly-Owned Subsidiary of E.I. Du Pont De Nemours and Company, Acquired the Securities Being Reported on by E.I. Du Pont De Nemours and Company in This Schedule 13g. E.I. Du Pont De Nemours and Company and Dupont Pharma, Inc., a Delaware Corporation, Are the Sole Partners of Dupont Pharmaceuticals Company. Dupont Chemical and Energy Operations, Inc. Directly Owns All the Outstanding Capital Stock of Dupont Pharma, Inc. E.I. Du Pont De Nemours and Company Directly Owns All the Outstanding Capital Stock of Dupont Chemical and Energy Operations, Inc

from SC 13G/A 1 page Exhibit 1 Joint Filing Agreement in Accordance With Rule 13d-1(f) Under the Securities Exchange Act of 1934, as Amended, the Persons Named Below Agree to the Joint Filing on Behalf of Each of Them of a Schedule 13g. This Joint Filing Agreement Shall Be Included as an Exhibit to Such Joint Filing. in Evidence Thereof, Each of the Undersigned, Being Duly Authorized, Hereby Execute This Agreement This 10th Day of February, 2000. Kos Holdings, Inc. By: /S/ Kathy Jaharis Ledes Kathy Jaharis Ledes Kos Investments, Inc. By: /S/ Kathy Jaharis Ledes Kathy Jaharis Ledes /S/ Michael Jaharis Michael Jaharis

from SC 13G 1 page Exhibit 1 Joint Filing Agreement in Accordance With Rule 13d-1(f) Under the Securities Exchange Act of 1934, as Amended, the Persons Named Below Agree to the Joint Filing on Behalf of Each of Them of a Schedule 13g. This Joint Filing Agreement Shall Be Included as an Exhibit to Such Joint Filing. in Evidence Thereof, Each of the Undersigned, Being Duly Authorized, Hereby Execute This Agreement This 10th Day of February, 1999. Kos Holdings, Inc. By: /S/ Kathy Jaharis Ledes Kathy Jaharis Ledes Kos Investments, Inc. By: /S/ Kathy Jaharis Ledes Kathy Jaharis Ledes /S/ Michael Jaharis Michael Jaharis

from S-1/A ~50 pages Underwriting Agreement

from S-1/A ~50 pages Underwriting agreement

from S-1/A ~50 pages Underwriting agreement