Orapharma Inc Watch

from SC 13G/A 1 page Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated February 14, 2003, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.001 Per Share, of Orapharma, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/A. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 14th Day of February, 2003. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President of Managing Member, Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly

from SC 13D/A 1 page Schedule II Information With Respect to Transactions Effected During the Past Sixty Days or Since the Most Recent Filing on Schedule 13d (1) Shares Purchased Average Date Sold(-) Price(2) Common Stock-Orapharma Inc. Gabelli Securities, Inc. 2/10/03 18,000- 7.4100 Gabelli Associates Ltd 2/10/03 265,621- 7.4100 2/05/03 16,000 7.3800 1/30/03 2,000 7.3800 Gaf II 2/10/03 5,300- 7.4100 Gabelli Associates Fund 2/10/03 336,751- 7.4100 2/05/03 15,000 7.3800 Gamco Investors, Inc. 2/05/03 10,000 7.3800 1/28/03 3,270 7.3800 1/24/03 5,400 7.3757 Mjg Associates, Inc. Gabelli Fund, Ldc 2/10/03 2,000- 7.4100 Gabelli Funds, LLC. Gabelli Mathers Fund 2/10/03 3,000- 7.4100 (1) the Dispositions on 2/10/03 Were in Connection With the Acquisition of the Issuer as Described in Item 5(a) of This Amendment to Schedule 13d. All Other Transactions Were Effected on the NASDAQ National Market. (2) Price Excludes Commission

from SC 13D >50 pages Agreement and Plan of Merger

from 8-A12G ~50 pages Underwriting agreement

from SC 13G 1 page <page> 1 <table> <s> <c> - Cusip No. 68554 E 10 13g Page 11 of 11 Pages - Exhibit 1 Agreement Pursuant to Rule 13d-1(k)(1) Under the Securities Exchange Act of 1934, the Undersigned Hereby Agree That Only One Statement Containing the Information Required by Schedule 13g Need Be Filed With Respect to the Ownership by Each of the Undersigned of Shares of Common Stock of Orapharma, Inc. This Agreement May Be Executed in Any Number of Counterparts, Each of Which Shall Be Deemed an Original. Executed This 7th Day of February, 2001. Frazier Healthcare II, L.P. By: Fhm II, L.L.C. Its General Partner By: Frazier Management, L.L.C. Its Managing Member By: Frazier & Company, Inc. Its Managing Member By: /S/ Alan D. Frazier Alan D. Frazier, President Fhm II. L.L.C. By: Frazier Management, L.L.C. Its Managing Member By: Frazier & Company, Inc. Its Managing Member By: /S/ Alan D. Frazier Alan D. Frazier, President Frazier Management, L.L.C. By: Frazier & Company, Inc. Its Managing Member By: /S/ Alan D. Frazier Alan D. Frazier, President Frazier & Company, Inc. By: /S/ Alan D. Frazier Alan D. Frazier, President, Director and Shareholder /S/ Alan D. Frazier Alan D. Frazier Page 11 of 11 Pages </Table>

from SC 13G 1 page Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on Schedule 13g, Dated December 14, 2000, (The "Schedule 13g"), With Respect to the Common Stock, Par Value $0.001 Per Share, of Orapharma, INC.IS, and Any Amendments Thereto Executed by Each of US Shall Be, Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to the Schedule 13g and Each Such Amendment. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g and Any Amendments Thereto, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 14th Day of December, 2000. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from S-1/A ~50 pages Underwriting Agreement