Praecis Pharmaceuticals Inc Watch

from SC 13D/A ~5 pages Agreement Regarding Joint Filing

from SC 13D 1 page October 10, 2006 Praecis Pharmaceuticals Incorporated 830 Winter Street Waltham, Ma 02451-1420 To: The Board of Directors of Praecis Pharmaceuticals Incorporated We Are Submitting This Brief Letter for You to Consider Prior to the Next Praecis Board of Directors Meeting. We Understand That at This Meeting You May Consider, Among Other Matters, Whether or Not to Continue the Current Business Plan of the Company or Pursue Other Strategic Options

from SC 13G/A 1 page Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated November 1, 2001, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.01 Per Share, of Praecis Pharmaceuticals Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/a . Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 1st Day of November, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G/A 1 page Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated November 1, 2001, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.01 Per Share, of Praecis Pharmaceuticals Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/a . Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 1st Day of November, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G/A 1 page Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated November 1, 2001, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.01 Per Share, of Praecis Pharmaceuticals Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/a . Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 1st Day of November, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from S-1/A ~50 pages Underwriting agreement

from S-1/A ~50 pages Underwriting agreement

from SC 13G 1 page Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on Schedule 13g, Dated December 13, 2000, (The "Schedule 13g"), With Respect to the Common Stock, Par Value $0.01 Per Share, of Praecis Pharmaceuticals Inc.IS, and Any Amendments Thereto Executed by Each of US Shall Be, Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to the Schedule 13g and Each Such Amendment. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g and Any Amendments Thereto, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 20th Day of December, 2000. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from S-1/A ~20 pages Underwriting agreement