Orbimed Advisers Inc Watch

from SC 13G/A 1 page Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on Schedule 13g/A, Dated February 10, 2003 (The "Schedule 13g/A"), With Respect to the Common Stock, $.001 Par Value, of Enzon Inc. Is, and Any Amendments Thereto Executed by Each of US Shall Be, Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to the Schedule 13g/a and Each Such Amendment. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/a and Any Amendments Thereto, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 10th Day of February, 2003. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member By: /S/ Samuel D. Isaly Name: Samuel D. Isaly

from SC 13G/A 1 page Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on Schedule 13g/A, Dated February 10, 2003(the "Schedule 13g/A"), With Respect to the Common Stock, $.001 Par Value, of Caliper Technologies Corp. Is, and Any Amendments Thereto Executed by Each of US Shall Be, Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to the Schedule 13g/a and Each Such Amendment. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/a and Any Amendments Thereto, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 10th Day of February, 2003. Orbimed Advisors Inc. By: Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: Name: Samuel D. Isaly Title: Managing Member By: Name: Samuel D. Isaly

from SC 13G/A 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated December 5, 2002, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.001 Per Share, of Triangle Pharmaceuticals Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/A. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 5th Day of December, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated November 29, 2002, (The "Schedule 13g"), With Respect to the Common Stock, Par Value $0.0001 Per Share, of Adolor Corporation Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 29th Day of November, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated November 29, 2002, (The "Schedule 13g"), With Respect to the Common Stock, Par Value $0.001 Per Share, of Ligand Pharmaceuticals Incorporated Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 29th Day of November, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated November 29, 2002, (The "Schedule 13g"), With Respect to the Common Stock, Par Value $0.01 Per Share, of Immunomedics Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 29th Day of November, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G/A 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated November 21, 2002, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.001 Per Share, of Discovery Laboratories, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/A. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 21st Day of November, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Samuel D. Isaly By: /S/ Samuel D. Isaly Samuel D. Isaly

from SC 13G/A 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on Schedule 13g/A, Dated November 21, 2002, (The "Schedule 13g/A"), With Respect to the Common Stock, $.001 Par Value, of Ciphergen Biosystems Inc. Is, and Any Amendments Thereto Executed by Each of US Shall Be, Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to the Schedule 13g/a and Each Such Amendment. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/a and Any Amendments Thereto, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 21st Day of November, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Samuel D. Isaly By: /S/ Samuel D. Isaly Samuel D. Isaly

from SC 13G/A 1 page Statement of Control Person

from SC 13G/A 1 page Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated July 30, 2002, (The "Schedule 13g/A"), With Respect to the Common Stock, No Par Value Per Share, of Depomed, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/A. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 30th Day of July, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Orbimed Capital LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Samuel D. Isaly By: /S/ Samuel D. Isaly Name: Samuel D. Isaly

from SC 13G 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated June 20, 2002, (The "Schedule 13g"), With Respect to the Common Stock, $.01 Par Value Per Share, of Enzon, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 20th Day of June, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated June 20, 2002, (The "Schedule 13g"), With Respect to the Common Stock, $.001 Par Value Per Share, of Bioenvision, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 20th Day of June, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Orbimed Capital LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Samuel D. Isaly By: /S/ Samuel D. Isaly Name: Samuel D. Isaly

from SC 13G/A 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated June 20, 2002, (The "Schedule 13g/A"), With Respect to the Common Stock, No Par Value Per Share, of Depomed, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/A. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 20th Day of June, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Orbimed Capital LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Samuel D. Isaly By: /S/ Samuel D. Isaly Name: Samuel D. Isaly

from SC 13G 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated June 12, 2002, (The "Schedule 13g"), With Respect to the Common Stock, No Par Value Per Share, of Pharmacopeia, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 12th Day of June, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G/A 1 page Ex-1.1 Otherdoc 2 0002.txt Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated June 4, 2002, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.001 Per Share, of Discovery Laboratories, Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/A. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 4th Day of June, 2002. Orbimed Advisors Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G 1 page Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated November 1, 2001, (The "Schedule 13g"), With Respect to the Common Stock, Par Value Nis 0.05 Per Share, of Given Imaging Ltd. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 1st Day of November, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member Orbimed Capital LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G 1 page Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated November 1, 2001, (The "Schedule 13g"), With Respect to the Common Stock, Par Value $0.0001 Per Share, of Argonaut Technologies Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 1st Day of November, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G/A 1 page Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated November 1, 2001, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.01 Per Share, of Praecis Pharmaceuticals Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/a . Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 1st Day of November, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G 1 page Joint Filing Agreement Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g, Dated November 1, 2001, (The "Schedule 13g"), With Respect to the Common Stock, Par Value Nis 0.05 Per Share, of Triangle Pharmaceuticals Inc. Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g. Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 1st Day of November 1, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member

from SC 13G/A 1 page Exhibit 1.1 Joint Filing Agreement the Undersigned Hereby Agree That the Statement on This Schedule 13g/A, Dated October 4, 2001, (The "Schedule 13g/A"), With Respect to the Common Stock, Par Value $0.001 Per Share, of Sangstat Medical Corporation Is Filed on Behalf of Each of US Pursuant to and in Accordance With the Provisions of Rule 13d-1(k) Under the Securities and Exchange Act of 1934, as Amended, and That This Agreement Shall Be Included as an Exhibit to This Schedule 13g/a . Each of the Undersigned Agrees to Be Responsible for the Timely Filing of the Schedule 13g/A, and for the Completeness and Accuracy of the Information Concerning Itself Contained Therein. This Agreement May Be Executed in Any Number of Counterparts, All of Which Taken Together Shall Constitute One and the Same Instrument. in Witness Whereof, the Undersigned Have Executed This Agreement as of the 4th Day of October, 2001. Orbimed Advisers Inc. By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: President Orbimed Advisors LLC By: /S/ Samuel D. Isaly Name: Samuel D. Isaly Title: Managing Member