EX-10
from 10KSB
3 pages
October 14, 2005 the Following Modifications in Section 5.3 (“Milestones”) Are Requested: 1. Milestone (2): Characterization of Target Protein(s) Based on Verifiable Protein Sequence(s). We Request the Milestone Date Be Moved From February 15, 2005 to December 31, 2005. 2. Milestone (3): The Filing of an FDA Application for the Current Format or Adoption of an Improved Alternate Diagnostic Format (Such as Elisa). We Request the Milestone Date Be Moved From May 15, 2005 to December 31, 2005. 3. Milestone (4): Cumulative Net Sales of at Least $350,000. We Request the Milestone Date Be Moved From November 15, 2005 to December 31, 2006. 4. Milestone (5): Cumulative Net Sales of at Least $1,300,000. We Request the Milestone Date Be Moved From November 15, 2006 to December 31, 2007. 5. Milestone (6): Increased Employee Staffing Levels From Those on May 15, 2004, Including a Senior Regulatory Person, 5 Scientists (Including Medical Technicians) and a Viable Customer Service Function (The Last of Which May Be Contracted Out). We Request the Milestone Be Eliminated. 6. Milestone (7): FDA Approval of Improved Alternate Diagnostic Format (Such as Elisa) or FDA Approval of Current Diagnostic Format. We Request the Milestone and Dates Be Reworded as Follows: FDA Approval of Current Diagnostic Format by December 31, 2008 or FDA Approval of Improved Alternate Diagnostic Format (Such as Elisa) by December 31, 2010. Milestone (1): First Commercial Sale by October 15, 2003 Was Completed on Schedule as Previously Reported to You. Ms. Robin Rasor the University of Michigan
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EX-10
from 10KSB
2 pages
May 12, 2004 1. Milestone (2): Characterization of Target Protein(s) Based on Verifiable Protein Sequence(s). We Request the Milestone Date Be Moved From May 15, 2004 to February 15, 2005. 2. Milestone (3): The Filing of an FDA Application for the Current Format or Adoption of an Improved Alternate Diagnostic Format (Such as Elisa). We Request the Milestone Date Be Moved From November 15, 2004 to May 15, 2005. 3. Milestone (4): Cumulative Net Sales of at Least $25,000. We Request the Milestone Date Be Moved From May 15, 2005 to November 15, 2005. 4. Milestone (5): Cumulative Net Sales of at Least $100,000. We Request the Milestone Date Be Moved From May 15, 2006 to November 15, 2006. 5. Milestone (6): Increased Employee Staffing Levels From Those on May 15, 2004, Including a Senior Regulatory Person, 5 Scientists (Including Medical Technicians) and a Viable Customer Service Function (The Last of Which May Be Contracted Out). We Request the Milestone Date Be Moved From May 15, 2005 to November 15, 2005. 6. Milestone (7): FDA Approval of Improved Alternate Diagnostic Format (Such as Elisa) or FDA Approval of Current Diagnostic Format. Mr. Brice Nelson the University of Michigan Office of Technology Transfer May 12, 2004 Page 2 of 2 Thank You for Your Consideration on This Amendment. if You Agree to These Modifications, Please Indicate Your Approval Below. Meanwhile, Please Contact Me if You Have Any Questions
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