Codexis Inc. Watch

from 10-K 59 pages [*] = Certain Marked Information Has Been Omitted From This Exhibit Because It Is Both Not Material and Is the Type That the Registrant Treats as Private or Confidential. Loan and Security Agreement Dated as of February 13, 2024 by and Among Innovatus Life Sciences Lending Fund I, LP, as Collateral Agent, Codexis, Inc., as Borrower and the Lenders Listed on Schedule 1.1 Hereof or Otherwise a Party Hereto From Time to Time [*] = Certain Marked Information Has Been Omitted From This Exhibit Because It Is Both Not Material and Is the Type That the Registrant Treats as Private or Confidential

from 10-Q 2 pages March 13, 2023 Codexis, Inc. 200 Penobscot Drive Redwood City, Ca 94063 Attn: Sri Ryali, CFO Fax: [***] Email: [***] Loan Number: 121143260 Borrower: Codexis, Inc

from 10-Q 3 pages Ninth Amendment to Loan and Security Agreement

from 10-Q 5 pages Eighth Amendment to Loan and Security Agreement

from 10-Q 4 pages Seventh Amendment to Loan and Security Agreement

from 10-Q 3 pages Sixth Amendment to Loan and Security Agreement

from 10-Q ~5 pages Fifth Amendment to Loan and Security Agreement

from 10-Q 5 pages Third Amendment to Loan and Security Agreement This Third Amendment to Loan and Security Agreement (This “Amendment”) Is Made Effective as of June 29, 2018 (The “Amendment Date”) and Made by and Among Western Alliance Bank, an Arizona Corporation (“Bank”) and Codexis, Inc., a Delaware Corporation (“Borrower”). Whereas, Bank and Borrower Have Entered Into That Certain Loan and Security Agreement, Dated as of June 30, 2017 (As Amended, Supplemented, Restated or Otherwise Modified From Time to Time, the “Loan Agreement”); and Whereas, Bank and Borrower Desire to Amend Certain Provisions of the Loan Agreement as Provided Herein and Subject to the Terms and Conditions Set Forth Herein; Now, Therefore, in Consideration of the Promises, Covenants and Agreements Contained Herein, and Other Good and Valuable Consideration, the Receipt and Adequacy of Which Are Hereby Acknowledged, Bank and Borrower Hereby Agree as Follows: 1. Capitalized Terms Used Herein but Not Otherwise Defined Shall Have the Respective Meanings Given to Them in the Loan Agreement. 2. Section 1.1 of the Loan Agreement Is Hereby Amended by Amending and Restating the Following Definition Therein as Follows

from 10-K 5 pages Second Amendment to Loan and Security Agreement

from 10-K 5 pages First Amendment to Loan and Security Agreement This First Amendment to Loan and Security Agreement (This “Amendment”) Is Made Effective as of September 28, 2017 (The “Amendment Date”) and Made by and Among Western Alliance Bank, an Arizona Corporation (“Bank”) and Codexis, Inc., a Delaware Corporation (“Borrower”). Whereas, Bank and Borrower Have Entered Into That Certain Loan and Security Agreement, Dated as of June 30, 2017 (As Amended, Supplemented, Restated or Otherwise Modified From Time to Time, the “Loan Agreement”); and Whereas, Bank and Borrower Desire to Amend Certain Provisions of the Loan Agreement as Provided Herein and Subject to the Terms and Conditions Set Forth Herein; Now, Therefore, in Consideration of the Promises, Covenants and Agreements Contained Herein, and Other Good and Valuable Consideration, the Receipt and Adequacy of Which Are Hereby Acknowledged, Bank and Borrower Hereby Agree as Follows: 1. Capitalized Terms Used Herein but Not Otherwise Defined Shall Have the Respective Meanings Given to Them in the Loan Agreement. 2. Section 1.1 of the Loan Agreement Is Hereby Amended by Amending and Restating the Following Definitions Therein as Follows: “Permitted Indebtedness” Means: (A) Indebtedness of Borrower in Favor of Bank Arising Under This Agreement or Any Other Loan Document; (B) Indebtedness Existing on the Closing Date and Disclosed in the Perfection Certificate on the Closing Date;

from 10-Q 4 pages First Amendment to Loan and Security Agreement

from 10-Q 51 pages Codexis, Inc., a Delaware Corporation Western Alliance Bank, an Arizona Corporation Loan and Security Agreement

from S-1/A 60 pages Loan and Security Agreement

from S-1 11 pages First Amendment to Loan and Security Agreement

from S-1 60 pages Loan and Security Agreement

from S-1/A 11 pages First Amendment to Loan and Security Agreement

from S-1/A 60 pages Loan and Security Agreement

from S-1 65 pages Loan and Security Agreement

from S-1 10 pages First Amendment to Loan and Security Agreement

from S-1 59 pages Loan and Security Agreement