Ocera Therapeutics, Inc. Watch

from 8-K 10 pages Warrant to Purchase Common Stock

from 8-K 10 pages Warrant to Purchase Stock

from S-3/A 114 pages Ocera Therapeutics, Inc. to Trustee Indenture Dated as of , 20 Subordinated Debt Securities

from S-3/A 106 pages Ocera Therapeutics, Inc. to Trustee Indenture Dated as of , 20 Senior Debt Securities

from 8-K 13 pages Ocera Therapeutics, Inc. Warrant to Purchase Common Stock

from 10-Q ~5 pages Ocera Therapeutics, Inc. Common Stock Purchase Warrant

from 10-Q ~5 pages Ocera Therapeutics, Inc. Common Stock Purchase Warrant

from 8-K 2 pages Ocera Therapeut Ics, Inc. Seal Corporate Delaware President and Chief Executive Officer Secretary This Certifies That Is the Record Holder of Incorporated Under the Laws of the State of Delaware See Reverse for Certain Definitions Cusip 67552a 10 8 Fully Paid and Nonassessable Shares of Common Stock, $0.00001 Par Value, of Ocera Therapeutics, Inc. Transferable on the Books of the Corporation by the Holder Hereof in Person or by Duly Authorized Attorney Upon Surrender of This Certificate Properly Endorsed. This Certificate Is Not Valid Until Countersigned by the Transfer Agent and Registered by the Registrar. Witness the Facsimile Seal of the Corporation and the Facsimile Signatures of Its Duly Authorized Officers. Dated: Ot Countersigned and Registered: Continental Stock Transfer & Trust Company (Jersey City, Nj) Transfer Agent and Registrar by Authorized Officer Ocera Therapeutics, Inc

from S-8 45 pages Tranzyme, Inc. Amended and Restated 2011 Stock Option and Incentive Plan

from S-3/A 114 pages Tranzyme, Inc. to Trustee Indenture Dated as of , 20 Subordinated Debt Securities

from S-3/A 106 pages Tranzyme, Inc. to Trustee Indenture Dated as of , 20 Senior Debt Securities

from 8-K 10 pages Warrant to Purchase Stock

from S-1/A 1 page President Secretary This Certifies That Is the Record Holder of Incorporated Under the Laws of the State of Delaware See Reverse for Certain Definitions Cusip 89413j 10 2 Fully Paid and Nonassessable Shares of Common Stock, $0.00001 Par Value, of Tranzyme, Inc. Transferable on the Books of the Corporation by the Holder Hereof in Person or by Duly Authorized Attorney Upon Surrender of This Certificate Properly Endorsed. This Certificate Is Not Valid Until Countersigned by the Transfer Agent and Registered by the Registrar. Witness the Facsimile Seal of the Corporation and the Facsimile Signatures of Its Duly Authorized Officers. Dated: T Countersigned and Registered: (Jersey City, Nj) Transfer Agent and Registrar by Authorized Officer Tranzyme, Inc. Continental Stock Transfer & Trust Company

from S-1 12 pages Warrant to Purchase Stock

from S-1 12 pages Warrant to Purchase Stock

from S-1 13 pages Warrant to Purchase Stock

from S-1 13 pages Warrant to Purchase Stock

from S-1 50 pages Fourth Amended and Restated Registration Rights Agreement