Advanced Life Sciences Holdings, Inc. Watch

from S-1 7 pages This Guaranty Dated as of September 9, 2010 (The “Guaranty”), Is Executed by the Undersigned (“Guarantor”), to and for the Benefit of the Leaders Bank (The “Lender”), Whose Address Is 2001 York Road, Suite 150, Oak Brook, Illinois 60523. Whereas, Lender Has Agreed to Continue to Extend Credit to Advanced Life Sciences, Inc. (The “Borrower”) in the Original Principal Amount of $8,500,000 (The “Loan”) Pursuant to the Terms of That Certain Second Amended and Restated Business Loan Agreement (The “Loan Agreement”); Whereas, Borrower Has Executed That Certain Second Amended and Restated Promissory Note in the Original Principal Amount of $8,500,000 in Favor of Lender (The “Note”); Whereas, Extension of Credit by the Lender to the Borrower Is Necessary and Desirable to the Finance the Borrower’s Operations and Will Inure to the Financial Benefit of the Guarantor; Now, Therefore, in Consideration of the Premises and the Agreements Herein and in Order to Induce the Lender to Continue Make and Maintain the Loan Pursuant to the Note, the Guarantor Hereby Agrees With Lender as Follows

from S-1 25 pages Second Amended and Restated Business Loan Agreement

from 10-Q 8 pages Commercial Guaranty Principal Loan Date Maturity Loan No. Call/Coll Account Officer Initials $ 10,000,000.00 10-23-2008 01-01-2011 1001234 4a/415 Jpp References in the Boxes Above Are for Lender’s Use Only and Do Not Limit the Applicability of This Document to Any Particular Loan or Item. Any Item Above Containing “***” Has Been Omitted Due to Text Length Limitations

from 10-Q 7 pages Commercial Guaranty Principal Loan Date Maturity Loan No. Call/Coll Account Officer Initials $ 10,000,000.00 10-23-2008 01-01-2011 1001234 4a/415 Jpp References in the Boxes Above Are for Lender’s Use Only and Do Not Limit the Applicability of This Document to Any Particular Loan or Item. Any Item Above Containing “***” Has Been Omitted Due to Text Length Limitations