Osiris Therapeutics, Inc. Watch

from S-8 1 page Second Amendment to Osiris Therapeutics, Inc. Amended and Restated 2006 Omnibus Plan

from S-8 1 page First Amendment to Osiris Therapeutics, Inc. Amended and Restated 2006 Omnibus Plan

from 10-K 2 pages Number 0 02007 Shares Void Osiris* Therapeutics, Inc. See Reverse for Incorporated Under the Laws of the State of Maryland Certain Definitions Common Stock Cusip 68827r 10 8 This Certifies That: Is the Owner of Void Fully Paid and Non-Assessable Shares of Common Stock of $.001 Par Value Each of Osiris Therapeutics, Inc. Transferable on the Books of the Corporation in Person or by Duly Authorized Attorney Upon Surrender of This Certificate Duly Endorsed or Assigned. This Certificate and the Shares Represented Hereby Are Subject to the Laws of the Corporation, as Now or Hereafter Amended. This Certificate Is Not Valid Until Countersigned by the Transfer Agent. Witness the Facsimile Seal of the Corporation and the Facsimile Signatures of Its Duly Authorized Officers. Dated: Countersigned: Stocktrans, a Broadridge Company 44 West Lancaster Ave., Ardmore, Pa 19003 Transfer Agent By: Authorized Signature Secretary & CFO President & CEO Osiris Therapeutics, Inc. Corporate Seal 2010 Maryland

from 10-Q 2 pages Fully Paid and Non-Assessable Shares of the Common Stock, Par Value $0.001 Per Share, of Osiris Therapeutics, Inc

from S-1/A 2 pages Number 738 Shares 0 Incorporated Under the Laws of the State of Delaware Osiris Therapeutics, Inc. Total Authorized Shares 90,000,000 Shares, $.001 Par Value Common Stock