Ra Pharmaceuticals, Inc. Watch

from 10-K 4 pages Description of Capital Stock

from S-3ASR 46 pages Ra Pharmaceuticals, Inc. Indenture Dated as of , 20 [ ] Trustee

from S-3 42 pages Ra Pharmaceuticals, Inc. Issuer and American Stock Transfer & Trust Company, LLC, Trustee Indenture Dated as of [·] Senior Debt Securities

from S-3 40 pages Ra Pharmaceuticals, Inc. Issuer and American Stock Transfer & Trust Company, LLC, Trustee Indenture Dated as of [·] Subordinated Debt Securities

from S-1/A 2 pages 001 Ra Pharmaceuticals, Inc. Incorporated Under the Laws of the State of Delaware $0.001 Par Value Per Share See Reverse for Certain Definitions This Certifies That Is the Owner of Fully Paid and Non-Assessable Common Stock, $0.001 Par Value of Ra Pharmaceuticals, Inc. Transferable on the Books of This Corporation in Person or by Attorney Upon Surrender of This Certificate Duly Endorsed or Assigned. This Certificate and the Shares Represented Hereby Are Subject to the Laws of the State of Delaware, and to the Certificate of Incorporation and the Bylaws of the Corporation, as Now or Hereafter Amended. This Certificate Is Not Valid Until Countersigned by the Traensfer Agent. in Witness Whereof, the Corporation Has Caused This Certificate to Be Signed by the Facsimile Signatures of Its Duly Authorized Officers and to Be Sealed With the Facsimile Seal of the Corporation. Dated: E President Secretary Countersigned: American Stock Transfer & Trust Company, LLC 6201 15th Avenue, Brooklyn, Ny 11219 by Transfer Agent and Registrar Authorized Officer Cusip 74933v 10 8

from S-1 12 pages Ra Pharmaceuticals, Inc. Common Stock Warrant Original Issue Date: December 1, 2010 Void After: 5 Pm Boston Time on December 1, 2020 This Warrant Is Issued to Stephen C. Blacklow

from S-1 11 pages Warrant to Purchase Common Stock

from S-1 32 pages Ra Pharmaceuticals, Inc. Amended and Restated Investors’ Rights Agreement

from DRS 12 pages Ra Pharmaceuticals, Inc. Common Stock Warrant Original Issue Date: December 1, 2010 Void After: 5 Pm Boston Time on December 1, 2020 This Warrant Is Issued to Stephen C. Blacklow

from DRS 11 pages Warrant to Purchase Common Stock

from DRS 32 pages Ra Pharmaceuticals, Inc. Amended and Restated Investors’ Rights Agreement