OptiNose Inc. Watch

from 8-K 16 pages Form of Pre-Funded Warrant to Purchase Common Stock

from 10-K 3 pages Description of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

from S-3 50 pages Optinose, Inc. and as Trustee Indenture

from 10-K 3 pages Description of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

from 8-K 17 pages Warrant Agency Agreement

from 8-K 19 pages Optinose, Inc. Form of Warrant to Purchase Common Stock

from 8-K 15 pages Common Stock Purchase Warrant Optinose, Inc

from 10-K 4 pages Description of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

from 8-K 18 pages Common Stock Purchase Warrant Optinose, Inc

from S-3 47 pages Optinose, Inc. and as Trustee Indenture Dated as of ,

from S-1/A 8 pages First Amendment to the Second Amended and Restated Registration Rights Agreement of Optinose, Inc

from S-1/A 5 pages First Amendment to the Second Amended and Restated Shareholders Agreement of Optinose, Inc

from S-1/A 7 pages First Amendment to the Second Amended and Restated Registration Rights Agreement of Optinose, Inc

from S-1/A 13 pages Stockholders’ Agreement

from S-1/A 4 pages First Amendment to the Second Amended and Restated Shareholders Agreement of Optinose, Inc

from S-1/A 2 pages Specimen Specimen N U M B E R See Reverse for Certain Definitions Incorporated Under the Laws of the State of Delaware C O M M O N S T O C K This Certifies That: Specimen Is the Owner of Fully Paid and Non-Assessable Shares of Common Stock, $0.001 Par Value Per Share, of Optinose, Inc. Transferable on the Books of the Corporation by the Holder Thereof in Person or by Duly Authorized Attorney Upon Surrender of This Certificate Duly Endorsed or Assigned. This Certificate and the Shares Represented Hereby Are Subject to the Laws of the State of Delaware, and to the Certificate of Incorporation and Bylaws of the Corporation, as Now or Hereafter Amended. This Certificate Is Not Valid Until Countersigned by the Transfer Agent. Witness the Facsimile Seal of the Corporation and the Facsimile Signatures of Its Duly Authorized Officers. Countersigned: Broadridge Corporate Issuer Solutions, Inc. 1717 Arch St., Ste. 1300, Philadelphia, Pa 19103 Transfer Agent Dated: By: Authorized Signature Chief Executive Officer President Cusip68404v100 Shares

from S-1 7 pages Warrant Optinose, Inc

from S-1 67 pages Optinose, Inc. Second Amended and Restated Shareholders’ Agreement Dated as of March 24, 2017

from S-1 32 pages Optinose, Inc. Second Amended and Restated Registration Rights Agreement Dated as of March 24, 2017

from DRS 7 pages Warrant Optinose, Inc