Aclaris Therapeutics Inc. Watch

from 10-K 3 pages Description of Aclaris Therapeutics, Inc. Capital Stock

from S-3ASR 18 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Debt Securities Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Debt Securities Warrant Agreement

from S-3ASR 20 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Preferred Stock Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Preferred Stock Warrant Agreement

from S-3ASR 20 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Common Stock Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Common Stock Warrant Agreement

from S-3ASR 48 pages Aclaris Therapeutics, Inc., Issuer and [Trustee], Trustee Indenture Dated as of [·], 20 Debt Securities

from 10-K 3 pages ​ Description of Aclaris Therapeutics, Inc. Capital Stock

from S-3 18 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Debt Securities Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Debt Securities Warrant Agreement

from S-3 20 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Preferred Stock Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Preferred Stock Warrant Agreement

from S-3 20 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Common Stock Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Common Stock Warrant Agreement

from S-3 48 pages Aclaris Therapeutics, Inc., Issuer and [Trustee], Trustee Indenture Dated as of [·], 20 Debt Securities

from 10-K 3 pages Description of Aclaris Therapeutics, Inc. Capital Stock

from S-3 21 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Debt Securities Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Debt Securities Warrant Agreement

from S-3 24 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Preferred Stock Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Preferred Stock Warrant Agreement

from S-3 23 pages Aclaris Therapeutics, Inc. and , as Warrant Agent Form of Common Stock Warrant Agreement Dated as of Aclaris Therapeutics, Inc. Form of Common Stock Warrant Agreement

from S-3 54 pages Aclaris Therapeutics, Inc., Issuer and [Trustee], Trustee Indenture Dated as of [·], 20 Debt Securities

from S-8 25 pages Aclaris Therapeutics, Inc. 2015 Equity Incentive Plan Adopted by the Board of Directors: September 15, 2015 Approved by the Stockholders: September 16, 2015 Effective Date: October 6, 2015

from S-1/A 1 page Specimen Specimen Number See Reverse for Certain Definitions Incorporated Under the Laws of the State of Delaware Commonstock This Certifies That: Specimen Is the Owner of Fully Paid and Non-Assessable Shares of the Common Stock, Par Value $.00001 Each of Aclaris Therapeutics, Inc. Transferable on the Books of the Corporation in Person or by Attorney Upon Surrender of This Certificate Duly Endorsed or Assigned. This Certificate and the Shares Represented Hereby Are Subject to the Laws of the State of Delaware, and to the Certificate of Incorporation and Bylaws of the Corporation, as Now or Hereafter Amended. This Certificate Is Not Valid Until Countersigned by the Transfer Agent. Witness the Facsimile Seal of the Corporation and the Facsimile Signatures of Its Duly Authorized Officers. Countersigned: Broadridge Corporate Issuer Solutions, Inc. 1717 Arch St., Ste. 1300, Philadelphia, Pa 19103 Transfer Agent Dated: By: Authorized Signature Secretary President Cusip 00461u 10 5 Shares