AveXis, Inc. Watch

from S-3ASR 18 pages AveXis, Inc. and , as Warrant Agent Form of Debt Securities Warrant Agreement Dated as of [ ], 20 AveXis, Inc. Form of Debt Securities Warrant Agreement

from S-3ASR 20 pages AveXis, Inc. and , as Warrant Agent Form of Preferred Stock Warrant Agreement Dated as of [ ], 20 AveXis, Inc. Form of Preferred Stock Warrant Agreement

from S-3ASR 20 pages AveXis, Inc. and , as Warrant Agent Form of Common Stock Warrant Agreement Dated as of [ ], 20 AveXis, Inc. Form of Common Stock Warrant Agreement

from S-3ASR 39 pages AveXis, Inc., Issuer and [Trustee], Trustee Indenture Dated as of , 20 Debt Securities

from S-8 29 pages AveXis, Inc. 2016 Equity Incentive Plan Adopted by the Board of Directors: January 29, 2016 Approved by the Stockholders: February 9, 2016 Ipo Date: February 10, 2016

from S-1/A 2 pages See Reverse Side for Certain Definitions Incorporated Under the Laws of the State of Delaware Fully Paid and Non-Assessable Shares of Common Stock, $0.0001 Par Value, of AveXis, Inc. Transferable on the Books of the Corporation Bycthe Hoolder Mhereof Imn Persoon or Bny Attorney Upon Surrender of This Certificate Properly Endorsed. This Certificate Is Not Valid Until Countersigned and Registered by the Transfer Agent and Registrar. in Witness Whereof, the Said Corporation Has Caused This Certificate to Be Signed by Facsimile Signatures of Its Duly Authorized Officers. Dated: Chief Financial Officer, Secretary and Treasurer Chief Executive Officer and President Countersigned and Registered: American Stock Transfer & Trust Company (Brooklyn, New York) Transfer Agent and Registrar by Authorized Signature This Certifies That S P E C I M E N Is the Owner of Cusip 05366u 10 0

from S-1 8 pages AveXis, Inc. Class B-2 Common Stock Warrant

from DRS 8 pages AveXis, Inc. Class B-2 Common Stock Warrant