Orchestra Therapeutics, Inc. Watch

from S-1 2 pages Statement of Board of Directors’ Approval of 2006 Bonuses

from 10-K 2 pages Statement of Warrant Exercise Inducement and Price Protection

from 10-K 2 pages Statement of Extension of Warrant Exercise Date

from 10-K 2 pages Statement of Extension of Warrant Exercise Date

from 10-K 4 pages Amendment No. 5 to Rights Agreement

from 10-K 2 pages Amendment of 2003 Stock Plan

from 10-Q 2 pages October 26, 2006 Robert Giordano Roi Ny 39 Broadway Suite 2410 New York, Ny 10006 Dear Bob, This Letter Is a Follow Up to Our Telephone Conversation on September 27, 2006. in Accordance With the Terms of Our Contract, We Hereby Notify You That We Will Terminate Our Current Contract With Roi Effective January 31, 2007

from 10-Q 2 pages Roi Group Associates Inc Amendment to Service Agreement Dated March 1, 2006

from S-1/A 4 pages Consulting Agreement

from S-1/A 2 pages The Immune Response Corporation “Mortgage Note”

from S-1/A 3 pages May 19, 2006 Spencer Trask Intellectual Capital Company, LLC 535 Madison Avenue, 18th Floor New York, Ny 10022 Attn: Kevin Kimberlin and Bruno Lerer, Esq. Re: Limited Recourse Interest Inducement Agreement Dear Kevin and Bruno

from S-1/A 2 pages May 22, 2006 Cornell Capital Partners, LP Attention: Mark Angelo 101 Hudson Street Suite 3700 Jersey City, Nj 07302 Dear Sirs: In Accordance With the May 1, 2006 Notice of Termination Pursuant to Article 10.2 (B) of the Standby Equity Distribution Agreement (Seda) Dated July 15, 2005, the Immune Response Corporation Hereby Terminates the Seda. Additionally, Please Return the Canceled Secured Debenture Document to My Attention as Well as the Two Immune Response Corporation Stock Certificates Currently Being Held in Escrow. the Certificate Amounts Are 9,326,000 and 4,959,705. Sincerely, /S/ Michael Green Michael K. Green Chief Operating Officer Chief Financial Officer Mkg/Kdm CC: David Gonzalez, Esq

from S-1 11 pages Stock Purchase Warrant

from S-1 14 pages The Immune Response Corporation 8% Senior Secured Convertible Promissory Note

from S-1 14 pages The Immune Response Corporation 8% Senior Secured Convertible Promissory Note

from S-1 3 pages The Immune Response Corporation 5931 Darwin Court Carlsbad, California 92008 February 22, 2006

from S-1 4 pages Amendment No. 1 to Additional Warrant Agreement

from S-1 14 pages Additional Warrant Agreement

from S-1 2 pages Amendment No. 1 to Warrant Agreement

from S-1 14 pages Warrant Agreement