Ionis Pharmaceuticals Inc. Watch

Other Revised 12/04/24 Ionis Pharmaceuticals, Inc. Presents at Piper Sandler 36th Annual Healthcare Conference, Dec-04-2024 09:00 AM 12/04/24 Other Revised 12/03/24 Ionis Pharmaceuticals, Inc. Presents at Citi's 2024 Global Healthcare Conference, Dec-03-2024 08:45 AM 12/03/24 Other Revised 11/20/24 Ionis Pharmaceuticals, Inc. Presents at Jefferies London Healthcare Conference 2024, Nov-20-2024 02:00 PM 11/20/24 Other Revised 11/18/24 Ionis Pharmaceuticals, Inc. Presents at Stifel 2024 Healthcare Conference, Nov-18-2024 01:50 PM 11/18/24 Other Revised 11/13/24 Ionis Pharmaceuticals, Inc. Presents at Guggenheim Securities Inaugural Healthcare Innovation Conference, Nov-13-2024 10:30 AM 11/13/24 Other Revised 11/13/24 Ionis Pharmaceuticals, Inc. Presents at UBS Global Healthcare Conference 2024, Nov-13-2024 07:15 AM 11/13/24 Earnings Revised 11/06/24 Ionis Pharmaceuticals, Inc., Q3 2024 Earnings Call, Nov 06, 2024 11/06/24 Other Revised 09/05/24 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 22nd Annual Global Healthcare Conference, Sep-05-2024 12:20 PM 09/05/24 Other Revised 09/04/24 Ionis Pharmaceuticals, Inc. Presents at Wells Fargo 2024 Healthcare Conference, Sep-04-2024 08:45 AM 09/04/24 Earnings Revised 08/01/24 Ionis Pharmaceuticals, Inc., Q2 2024 Earnings Call, Aug 01, 2024 08/01/24 Other Revised 07/22/24 Ionis Pharmaceuticals, Inc. - Special Call 07/22/24 Other Revised 11/02/24 Ionis Pharmaceuticals, Inc. Presents at TD Cowen’s Genetic Medicines & RNA Summit, Jun-20-2024 03:30 PM 06/20/24 Other Revised 06/11/24 Ionis Pharmaceuticals, Inc. Presents at Goldman Sachs 45th Annual Global Healthcare Conference, Jun-10-2024 through Jun-13-2024 06/11/24 Other Revised 06/06/24 Ionis Pharmaceuticals, Inc. - Special Call 06/06/24 Other Revised 05/31/24 Ionis Pharmaceuticals, Inc. - Special Call 05/31/24 Other Revised 09/05/24 Ionis Pharmaceuticals, Inc. Presents at Bank of America Health Care Conference 2024, May-14-2024 10:40 AM 05/14/24 Other Revised 05/14/24 Ionis Pharmaceuticals, Inc. Presents at 2024 RBC Capital Markets Global Healthcare Conference, May-14-2024 10:30 AM 05/14/24 Earnings Revised 05/07/24 Ionis Pharmaceuticals, Inc., Q1 2024 Earnings Call, May 07, 2024 05/07/24 Other Revised 04/08/24 Ionis Pharmaceuticals, Inc. Presents at 23rd Annual Needham Virtual Healthcare Conference, Apr-08-2024 03:00 PM 04/08/24 Other Revised 04/08/24 Ionis Pharmaceuticals, Inc. - Special Call 04/08/24 Other Revised 03/20/24 Ionis Pharmaceuticals, Inc. Presents at Stifel Virtual 2024 CNS Day, Mar-20-2024 10:30 AM 03/20/24 Other Revised 03/07/24 Ionis Pharmaceuticals, Inc. Presents at TD Cowen 44th Annual Health Care Conference 2024, Mar-05-2024 11:10 AM 03/05/24 Earnings Revised 02/21/24 Ionis Pharmaceuticals, Inc., 2023 Earnings Call, Feb 21, 2024 02/21/24 Other Revised 04/26/24 Ionis Pharmaceuticals, Inc. Presents at J.P. Morgan 42nd Annual Healthcare Conference 2024, Jan-10-2024 03:00 PM 01/10/24

Other Revised 02/12/24 Ionis Pharmaceuticals, Inc. Presents at 2023 BMO Growth & ESG Conference, Dec-04-2023 12/03/23 Other Revised 02/08/24 Ionis Pharmaceuticals, Inc. Presents at Piper Sandler 35th Annual Healthcare Conference, Nov-28-2023 10:00 AM 11/28/23 Other Revised 11/14/23 Ionis Pharmaceuticals, Inc. Presents at The Stifel 2023 Annual Healthcare Conference, Nov-14-2023 10:55 AM 11/14/23 Other Revised 11/07/23 Ionis Pharmaceuticals, Inc. Presents at Guggenheim Securities 5th Annual Inflammation, Neurology & Immunology Conference, Nov-07-2023 11:10 AM 11/07/23 Earnings Revised 11/02/23 Ionis Pharmaceuticals, Inc., Q3 2023 Earnings Call, Nov 02, 2023 11/02/23 Other Revised 10/05/23 Ionis Pharmaceuticals, Inc. - Analyst/Investor Day 10/04/23 Other Revised 09/26/23 Ionis Pharmaceuticals, Inc. - Special Call 09/26/23 Other Revised 09/12/23 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 21st Annual Global Healthcare Conference 2023, Sep-12-2023 12:15 PM 09/12/23 Other Revised 09/07/23 Ionis Pharmaceuticals, Inc. Presents at Citi 18th Annual BioPharma Conference, Sep-07-2023 01:50 PM 09/07/23 Other Revised 04/04/24 Ionis Pharmaceuticals, Inc. Presents at Wells Fargo Securities Healthcare Conference 2023, Sep-06-2023 12:45 PM 09/06/23 Earnings Revised 08/09/23 Ionis Pharmaceuticals, Inc., Q2 2023 Earnings Call, Aug 09, 2023 08/09/23 Other Revised 07/10/23 Ionis Pharmaceuticals, Inc. Presents at TD Cowen’s 2nd Annual RNA Therapeutics Summit, Jul-10-2023 10:25 AM 07/10/23 Other Revised 06/12/23 Ionis Pharmaceuticals, Inc. Presents at Goldman Sachs 44th Annual Global Healthcare Conference, Jun-12-2023 09:20 AM 06/12/23 Other Revised 06/01/23 Ionis Pharmaceuticals, Inc. - Special Call 06/01/23 Other Revised 05/16/23 Ionis Pharmaceuticals, Inc. Presents at RBC Capital Markets Global Healthcare Conference 2023, May-16-2023 10:00 AM 05/16/23 Earnings Revised 08/04/24 Ionis Pharmaceuticals, Inc., Q1 2023 Earnings Call, May 03, 2023 05/03/23 Other Revised 07/05/23 Ionis Pharmaceuticals, Inc. - Special Call 04/25/23 Other Revised 04/17/23 Ionis Pharmaceuticals, Inc. Presents at 22nd Annual Needham Healthcare Conference, Apr-17-2023 11:00 AM 04/17/23 Other Revised 04/25/23 Ionis Pharmaceuticals, Inc. Presents at Guggenheim Healthcare Talks Genomic Medicines and Rare Disease Days, Apr-04-2023 10:45 AM 04/04/23 Other Revised 03/29/23 Ionis Pharmaceuticals, Inc. Presents at Stifel 2023 Virtual CNS Days, Mar-29-2023 10:00 AM 03/29/23 Other Revised 03/15/23 Ionis Pharmaceuticals, Inc. Presents at Oppenheimer 33rd Annual Healthcare Conference, Mar-15-2023 10:40 AM 03/15/23 Other Revised 03/07/23 Ionis Pharmaceuticals, Inc. Presents at Cowen 43rd Annual Healthcare Conference, Mar-07-2023 09:50 AM 03/07/23 Earnings Revised 01/09/24 Ionis Pharmaceuticals, Inc., Q4 2022 Earnings Call, Feb 22, 2023 02/22/23 Other Revised 01/11/23 Ionis Pharmaceuticals, Inc. Presents at 41st Annual J.P. Morgan Healthcare Conference, Jan-11-2023 09:45 AM 01/11/23

Other Revised 12/07/22 Ionis Pharmaceuticals, Inc. Presents at NASDAQ 47th Investor Conference, Dec-07-2022 02:00 PM 12/07/22 Other Revised 12/06/22 Ionis Pharmaceuticals, Inc. Presents at BMO 2022 Growth & ESG Conference, Dec-07-2022 12/06/22 Other Revised 11/29/22 Ionis Pharmaceuticals, Inc. Presents at Piper Sandler 34th Annual Healthcare Conference, Nov-29-2022 10:00 AM 11/29/22 Other Revised 11/29/22 Ionis Pharmaceuticals, Inc. Presents at 5th Annual Evercore ISI HealthCONx Conference 2022, Nov-29-2022 09:40 AM 11/29/22 Other Revised 11/15/22 Ionis Pharmaceuticals, Inc. Presents at Stifel 2022 Healthcare Conference, Nov-15-2022 11:30 AM 11/15/22 Other Revised 11/14/22 Ionis Pharmaceuticals, Inc. Presents at Guggenheim Healthcare Talks: 4th Annual Immunology and Neurology Day, Nov-14-2022 02:10 PM 11/14/22 Other Revised 11/14/22 Ionis Pharmaceuticals, Inc. - Special Call 11/14/22 Earnings Revised 11/09/22 Ionis Pharmaceuticals, Inc., Q3 2022 Earnings Call, Nov 09, 2022 11/09/22 Other Revised 09/12/22 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 20th Annual Global Healthcare Conference, Sep-12-2022 02:15 PM 09/12/22 Other Revised 09/08/22 Ionis Pharmaceuticals, Inc. Presents at Citi's 17th Annual BioPharma Conference, Sep-08-2022 08:50 AM 09/08/22 Other Revised 09/07/22 Ionis Pharmaceuticals, Inc. Presents at 2022 Wells Fargo Healthcare Conference, Sep-07-2022 11:00 AM 09/07/22 Earnings Revised 08/09/22 Ionis Pharmaceuticals, Inc., Q2 2022 Earnings Call, Aug 09, 2022 08/09/22 Other Revised 07/20/22 Ionis Pharmaceuticals, Inc. Presents at H.C. Wainwright 1st Annual Hereditary Angioedema (HAE) Conference, Jul-20-2022 01:00 PM 07/20/22 Other Revised 06/02/22 Ionis Pharmaceuticals, Inc. - Special Call 06/02/22 Other Revised 05/11/22 Ionis Pharmaceuticals, Inc. Presents at Bank of America 2022 Healthcare Conference, May-11-2022 10:00 AM 05/11/22 Earnings Revised 05/04/22 Ionis Pharmaceuticals, Inc., Q1 2022 Earnings Call, May 04, 2022 05/04/22 Other Revised 04/11/22 Ionis Pharmaceuticals, Inc. Presents at Needham 21st Annual Healthcare Conference, Apr-11-2022 10:15 AM 04/11/22 Other Revised 04/01/22 Ionis Pharmaceuticals, Inc. Presents at Guggenheim Healthcare Talks Genomic Medicines and Rare Disease Day, Apr-01-2022 01:00 PM 04/01/22 Other Revised 03/28/22 Ionis Pharmaceuticals, Inc. Presents at Stifel CNS Days, Mar-28-2022 11:00 AM 03/28/22 Other Revised 03/07/22 Ionis Pharmaceuticals, Inc. Presents at 42nd Annual Cowen Health Care Conference, Mar-07-2022 09:10 AM 03/07/22 Earnings Revised 02/24/22 Ionis Pharmaceuticals, Inc., Q4 2021 Earnings Call, Feb 24, 2022 02/24/22 Other Revised 01/12/22 Ionis Pharmaceuticals, Inc. Presents at JPMorgan 40th Annual Healthcare Conference, Jan-12-2022 09:45 AM 01/12/22

Other Revised 05/24/24 Ionis Pharmaceuticals, Inc. - Analyst/Investor Day 12/09/21 Other Revised 08/08/24 Ionis Pharmaceuticals, Inc. - Special Call 12/07/21 Other Revised 11/30/21 Ionis Pharmaceuticals, Inc. Presents at 4th Annual Evercore ISI HealthCONx Virtual Conference, Nov-30-2021 10:30 AM 11/30/21 Other Revised 11/15/21 Ionis Pharmaceuticals, Inc. Presents at Stifel 2021 Virtual Healthcare Conference, Nov-15-2021 10:40 AM 11/15/21 Earnings Revised 11/03/21 Ionis Pharmaceuticals, Inc., Q3 2021 Earnings Call, Nov 03, 2021 11/03/21 Other Revised 09/13/21 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 19th Annual Global Healthcare Conference, Sep-13-2021 02:00 PM 09/13/21 Other Revised 09/10/21 Ionis Pharmaceuticals, Inc. Presents at Wells Fargo 2021 Virtual Healthcare Conference, Sep-10-2021 02:00 PM 09/10/21 Earnings Revised 08/04/21 Ionis Pharmaceuticals, Inc., Q2 2021 Earnings Call, Aug 04, 2021 08/04/21 Other Revised 06/22/21 Ionis Pharmaceuticals, Inc. Presents at BMO Biopharma Day: Spotlight on Rare Disease and Ophthalmology, Jun-22-2021 12:00 PM 06/22/21 Other Revised 06/15/21 Ionis Pharmaceuticals, Inc. Presents at Nasdaq 44th Virtual Investor Conference, Jun-15-2021 10:30 AM 06/15/21 Other Revised 06/09/21 Ionis Pharmaceuticals, Inc. Presents at Goldman Sachs 42nd Annual Global Healthcare Conference, Jun-09-2021 01:20 PM 06/09/21 Other Revised 06/02/21 Ionis Pharmaceuticals, Inc. - Special Call 06/02/21 Other Revised 06/01/21 Ionis Pharmaceuticals, Inc. Presents at William Blair & Company 41st Annual Growth Stock Conference, Jun-01-2021 11:00 AM 06/01/21 Other Revised 05/19/21 Ionis Pharmaceuticals, Inc. Presents at RBC Capital Markets 2021 Global Healthcare Conference, May-19-2021 10:55 AM 05/19/21 Other Revised 05/12/21 Ionis Pharmaceuticals, Inc. Presents at BofA Securities 2021 Virtual Health Care Conference, May-12-2021 03:30 PM 05/12/21 Earnings Revised 05/05/21 Ionis Pharmaceuticals, Inc., Q1 2021 Earnings Call, May 05, 2021 05/05/21 Other Revised 04/12/21 Ionis Pharmaceuticals, Inc. Presents at 20th Annual Needham Virtual Healthcare Conference, Apr-12-2021 10:15 AM 04/12/21 Other Revised 04/05/21 Ionis Pharmaceuticals, Inc. - Special Call 04/05/21 Other Revised 04/01/21 Ionis Pharmaceuticals, Inc. Presents at Stifel's 3rd Annual CNS Day, Apr-01-2021 12:00 PM 04/01/21 Other Revised 03/29/21 Ionis Pharmaceuticals, Inc. Presents at J.P. Morgan 10th Annual Napa Valley Forum, Mar-29-2021 04:00 PM 03/29/21 Other Revised 03/22/21 Ionis Pharmaceuticals, Inc. - Special Call 03/22/21 Other Revised 03/17/21 Ionis Pharmaceuticals, Inc. Presents at Oppenheimer 31st Annual Healthcare Conference, Mar-17-2021 10:40 AM 03/17/21 Other Revised 02/26/21 Ionis Pharmaceuticals, Inc. Presents at SVB Leerink 10th Annual Global Healthcare Conference 2021, Feb-26-2021 11:20 AM 02/26/21 Earnings Revised 02/24/21 Ionis Pharmaceuticals, Inc., Q4 2020 Earnings Call, Feb 24, 2021 02/24/21 Other Revised 01/12/21 Ionis Pharmaceuticals, Inc. Presents at 39th Annual JPMorgan Virtual Healthcare Conference, Jan-12-2021 12:40 PM 01/12/21

Other Revised 12/08/20 Ionis Pharmaceuticals, Inc. Presents at BMO Growth and ESG Conference, Dec-08-2020 03:00 PM 12/08/20 Other Revised 12/07/20 Ionis Pharmaceuticals, Inc. - Analyst/Investor Day 12/07/20 Other Revised 12/03/20 Ionis Pharmaceuticals, Inc. Presents at Piper Sandler 32nd Annual Virtual Healthcare Conference, Dec-03-2020 10:30 AM 12/03/20 Other Revised 12/01/20 Ionis Pharmaceuticals, Inc. Presents at Evercore ISI 3rd Annual HealthCONx, Dec-01-2020 02:40 PM 12/01/20 Other Revised 11/16/20 Ionis Pharmaceuticals, Inc. Presents at 2020 Stifel Virtual Healthcare Conference, Nov-16-2020 04:00 PM 11/16/20 Earnings Revised 11/04/20 Ionis Pharmaceuticals, Inc., Q3 2020 Earnings Call, Nov 04, 2020 11/04/20 Other Revised 09/22/20 Ionis Pharmaceuticals, Inc. Presents at Oppenheimer Fall Healthcare Life Sciences & MedTech Summit, Sep-22-2020 02:30 PM 09/22/20 Other Revised 09/18/20 Ionis Pharmaceuticals, Inc. Presents at BofA Global Healthcare Conference, Sep-18-2020 04:35 PM 09/18/20 Other Revised 09/14/20 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 18th Annual Global Healthcare Conference, Sep-14-2020 03:00 PM 09/14/20 Other Revised 09/10/20 Ionis Pharmaceuticals, Inc. Presents at Wells Fargo Securities 2020 Virtual Healthcare Conference, Sep-10-2020 01:20 PM 09/10/20 Other Revised 09/09/20 Ionis Pharmaceuticals, Inc. Presents at Citi 15th Annual Biopharma Virtual Conference 2020, Sep-09-2020 02:25 PM 09/09/20 Other Revised 09/02/20 Ionis Pharmaceuticals, Inc. - Special Call 09/02/20 Other Revised 08/27/20 Ionis Pharmaceuticals, Inc. - Special Call 08/27/20 Earnings Revised 08/05/20 Ionis Pharmaceuticals, Inc., Q2 2020 Earnings Call, Aug 05, 2020 08/05/20 Other Revised 07/14/20 Ionis Pharmaceuticals, Inc. - Special Call 07/14/20 Other Revised 06/23/20 Ionis Pharmaceuticals, Inc. Presents at BMO 2020 Prescriptions for Success Healthcare Conference, Jun-23-2020 02:00 PM 06/23/20 Other Revised 06/10/20 Ionis Pharmaceuticals, Inc. Presents at Goldman Sachs 41st Annual Global Healthcare Conference, Jun-10-2020 01:40 PM 06/10/20 Other Revised 06/10/20 Ionis Pharmaceuticals, Inc. Presents at William Blair 40th Annual Growth Stock Virtual Conference, Jun-10-2020 11:20 AM 06/10/20 Other Revised 06/04/20 Ionis Pharmaceuticals, Inc. - Special Call 06/04/20 Other Revised 05/13/20 Ionis Pharmaceuticals, Inc. Presents at BofA Securities 2020 Health Care Conference, May-13-2020 01:40 PM 05/13/20 Earnings Revised 05/06/20 Ionis Pharmaceuticals, Inc., Q1 2020 Earnings Call, May 06, 2020 05/06/20 Other Revised 04/15/20 Ionis Pharmaceuticals, Inc. - Special Call 04/15/20 Other Revised 04/14/20 Ionis Pharmaceuticals, Inc. Presents at 19th Annual Needham Healthcare Conference, Apr-14-2020 01:30 PM 04/14/20 Other Revised 03/04/20 Ionis Pharmaceuticals, Inc. Presents at Cowen and Company 40th Annual Health Care Conference, Mar-04-2020 10:40 AM 03/04/20 Earnings Revised 02/26/20 Ionis Pharmaceuticals, Inc., 2019 Earnings Call, Feb 26, 2020 02/26/20 Other Revised 01/15/20 Ionis Pharmaceuticals, Inc. Presents at 38th Annual J.P Morgan Healthcare Conference, Jan-15-2020 07:30 AM 01/15/20

Other Revised 12/13/19 Ionis Pharmaceuticals, Inc. - Special Call 12/13/19 Other Revised 11/21/19 Ionis Pharmaceuticals, Inc. Presents at Jefferies 2019 London Healthcare Conference, Nov-21-2019 03:20 PM 11/21/19 Other Revised 11/19/19 Ionis Pharmaceuticals, Inc. Presents at Stifel 2019 Healthcare Conference, Nov-19-2019 09:45 AM 11/19/19 Earnings Revised 11/06/19 Ionis Pharmaceuticals, Inc., Q3 2019 Earnings Call, Nov 06, 2019 11/06/19 Other Revised 09/10/19 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 17th Annual Global Healthcare Conference, Sep-10-2019 12:20 PM 09/10/19 Other Revised 09/05/19 Ionis Pharmaceuticals, Inc. Presents at 14th Annual Wells Fargo Securities Healthcare Conference, Sep-05-2019 09:45 AM 09/05/19 Earnings Revised 08/07/19 Ionis Pharmaceuticals, Inc., Q2 2019 Earnings Call, Aug 07, 2019 08/07/19 Other Revised 06/25/19 Ionis Pharmaceuticals, Inc. Presents at BMO 2019 Prescriptions for Success Healthcare Conference, Jun-25-2019 09:20 AM 06/25/19 Other Revised 06/06/19 Ionis Pharmaceuticals, Inc. - Shareholder/Analyst Call 06/06/19 Earnings Revised 05/09/19 Ionis Pharmaceuticals, Inc., Q1 2019 Earnings Call, May 09, 2019 05/09/19 Other Revised 05/07/19 Ionis Pharmaceuticals, Inc. - Special Call 05/07/19 Other Revised 04/09/19 Ionis Pharmaceuticals, Inc. Presents at 18th Annual Needham Healthcare Conference, Apr-09-2019 12:50 PM 04/09/19 Other Revised 03/13/19 Ionis Pharmaceuticals, Inc. Presents at 39th Annual Cowen Health Care Conference, Mar-13-2019 10:00 AM 03/13/19 Earnings Revised 02/27/19 Ionis Pharmaceuticals, Inc., 2018 Earnings Call, Feb 27, 2019 02/27/19 Other Revised 01/07/19 Ionis Pharmaceuticals, Inc. Presents at The 37th Annual J.P. Morgan Healthcare Conference, Jan-07-2019 04:00 PM 01/07/19

Other Revised 12/12/18 Ionis Pharmaceuticals, Inc. Presents at BMO Prescriptions for Success Healthcare Conference, Dec-12-2018 08:40 AM 12/12/18 Other Revised 12/07/18 Ionis Pharmaceuticals, Inc. - Analyst/Investor Day 12/07/18 Other Revised 12/05/18 Ionis Pharmaceuticals, Inc. Presents at Citi Global Healthcare Conference, Dec-05-2018 01:25 PM 12/05/18 Other Revised 11/28/18 Ionis Pharmaceuticals, Inc. Presents at 30th Annual Piper Jaffray Healthcare Conference, Nov-28-2018 10:00 AM 11/28/18 Other Revised 11/14/18 Ionis Pharmaceuticals, Inc. Presents at Stifel 2018 Healthcare Conference, Nov-14-2018 11:00 AM 11/14/18 Other Revised 11/14/18 Ionis Pharmaceuticals, Inc. Presents at Jefferies 2018 London Healthcare Conference, Nov-14-2018 09:20 AM 11/14/18 Earnings Revised 11/06/18 Ionis Pharmaceuticals, Inc., Q3 2018 Earnings Call, Nov 06, 2018 11/06/18 Other Revised 10/05/18 Akcea Therapeutics, Inc., Ionis Pharmaceuticals, Inc. - Special Call 10/05/18 Other Revised 09/12/18 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 16th Annual Global Healthcare Conference, Sep-12-2018 09:20 AM 09/12/18 Other Revised 09/05/18 Ionis Pharmaceuticals, Inc. Presents at 2018 Wells Fargo Securities Healthcare Conference, Sep-05-2018 02:25 PM 09/05/18 Earnings Revised 08/07/18 Ionis Pharmaceuticals, Inc., Q2 2018 Earnings Call, Aug 07, 2018 08/07/18 Other Revised 05/23/18 Ionis Pharmaceuticals, Inc. - Shareholder/Analyst Call 05/23/18 Earnings Revised 05/04/18 Ionis Pharmaceuticals, Inc., Q1 2018 Earnings Call, May 04, 2018 05/04/18 Other Revised 04/20/18 Ionis Pharmaceuticals, Inc. - Special Call 04/20/18 Other Revised 03/27/18 Ionis Pharmaceuticals, Inc. Presents at 17th Annual Needham Healthcare Conference, Mar-27-2018 11:30 AM 03/27/18 Other Revised 03/13/18 Ionis Pharmaceuticals, Inc. Presents at 38th Annual Cowen and Company Healthcare Conference, Mar-13-2018 10:40 AM 03/13/18 Other Revised 03/02/18 Ionis Pharmaceuticals, Inc. - Special Call 03/02/18 Earnings Revised 02/27/18 Ionis Pharmaceuticals, Inc., 2017 Earnings Call, Feb 27, 2018 02/27/18 Other Revised 01/08/18 Ionis Pharmaceuticals, Inc. Presents at 36th Annual J.P. Morgan Healthcare Conference, Jan-08-2018 07:30 AM 01/08/18

Other Revised 12/14/17 Ionis Pharmaceuticals, Inc. Presents at BMO Capital Markets 2017 Prescriptions for Success Healthcare Conference, Dec-14-2017 01:30 PM 12/14/17 Other Revised 11/30/17 Ionis Pharmaceuticals, Inc. Presents at Evercore ISI Biopharma Catalyst/Deep Dive Conference, Nov-30-2017 08:45 AM 11/30/17 Other Revised 11/15/17 Ionis Pharmaceuticals, Inc. Presents at Stifel 2017 Healthcare Conference, Nov-15-2017 08:00 AM 11/15/17 Earnings Revised 11/07/17 Ionis Pharmaceuticals, Inc., Q3 2017 Earnings Call, Nov 07, 2017 11/07/17 Other Revised 11/02/17 Ionis Pharmaceuticals, Inc. - Special Call 11/02/17 Other Revised 09/13/17 Ionis Pharmaceuticals, Inc. Presents at Morgan Stanley 15th Annual Global Healthcare Conference, Sep-13-2017 02:10 PM 09/13/17 Other Revised 09/06/17 Ionis Pharmaceuticals, Inc. Presents at 2017 Wells Fargo Healthcare Conference, Sep-06-2017 11:25 AM 09/06/17 Other Revised 08/24/17 Ionis Pharmaceuticals, Inc. Presents at Southern California Investor Conference 2017, Aug-24-2017 10:00 AM 08/24/17 Other Revised 08/11/17 Ionis Pharmaceuticals, Inc. - Special Call 08/11/17 Earnings Revised 08/08/17 Ionis Pharmaceuticals, Inc., Q2 2017 Earnings Call, Aug 08, 2017 08/08/17 Other Revised 05/24/17 Ionis Pharmaceuticals, Inc. - Shareholder/Analyst Call 05/24/17 Other Revised 05/17/17 Ionis Pharmaceuticals, Inc. Presents at Bank of America Merrill Lynch 2017 Healthcare Conference, May-17-2017 09:20 AM 05/17/17 Other Revised 05/15/17 Ionis Pharmaceuticals, Inc. - Special Call 05/15/17 Earnings Revised 05/09/17 Ionis Pharmaceuticals, Inc., Q1 2017 Earnings Call, May 09, 2017 05/09/17 Other Revised 04/05/17 Ionis Pharmaceuticals, Inc. Presents at 16th Annual Needham Healthcare Conference, Apr-05-2017 09:20 AM 04/05/17 Other Revised 03/08/17 Ionis Pharmaceuticals, Inc. Presents at Cowen and Company 37th Annual Health Care Conference, Mar-08-2017 08:00 AM 03/08/17 Other Revised 03/06/17 Ionis Pharmaceuticals, Inc. - Special Call 03/06/17 Earnings Revised 02/28/17 Ionis Pharmaceuticals, Inc., Q4 2016 Earnings Call, Feb 28, 2017 02/28/17 Other Revised 01/09/17 Ionis Pharmaceuticals, Inc. Presents at 35th Annual JP Morgan Healthcare Conference, Jan-09-2017 10:00 AM 01/09/17 Other Revised 01/06/17 Ionis Pharmaceuticals, Inc. - Special Call 01/06/17 Other Revised 01/05/17 Ionis Pharmaceuticals, Inc. - Special Call 01/05/17

Earnings Revised 11/09/16 Ionis Pharmaceuticals, Inc., Q3 2016 Earnings Call, Nov 09, 2016 11/09/16 Other Revised 09/13/16 Ionis Pharmaceuticals, Inc. Presents at The 2016 Morgan Stanley Global Healthcare Conference, Sep-13-2016 12:55 PM 09/13/16 Earnings Revised 08/09/16 Ionis Pharmaceuticals, Inc., Q2 2016 Earnings Call, Aug 09, 2016 08/09/16 Other Revised 07/13/16 Ionis Pharmaceuticals, Inc. - Analyst/Investor Day 07/13/16 Other Revised 06/08/16 Ionis Pharmaceuticals, Inc. Presents at Goldman Sachs 37th Annual Global Healthcare Conference, Jun-08-2016 02:40 PM 06/08/16 Other Revised 06/03/16 Ionis Pharmaceuticals, Inc. - Shareholder/Analyst Call 06/03/16 Other Revised 05/26/16 Ionis Pharmaceuticals, Inc. - Special Call 05/26/16 Other Revised 05/05/16 Ionis Pharmaceuticals, Inc. Presents at Deutsche Bank 41st Annual Health Care Conference 2016, May-05-2016 08:00 AM 05/05/16 Earnings Revised 05/04/16 Ionis Pharmaceuticals, Inc., Q1 2016 Earnings Call, May 04, 2016 05/04/16 Other Revised 04/21/16 Ionis Pharmaceuticals, Inc. - Special Call 04/21/16 Other Revised 03/15/16 Ionis Pharmaceuticals, Inc. Presents at Barclays Global Healthcare Conference, Mar-15-2016 02:35 PM 03/15/16 Earnings Revised 02/25/16 Ionis Pharmaceuticals, Inc., Q4 2015 Earnings Call, Feb 25, 2016 02/25/16 Other Revised 01/11/16 Ionis Pharmaceuticals, Inc. Presents at JPMorgan 34th Annual Healthcare Conference, Jan-11-2016 02:30 PM 01/11/16

Other Revised 11/11/15 Isis Pharmaceuticals, Inc. Presents at Credit Suisse 24th Annual Healthcare Conference, Nov-11-2015 01:00 PM 11/11/15 Earnings Revised 11/09/15 Isis Pharmaceuticals, Inc., Q3 2015 Earnings Call, Nov 09, 2015 11/09/15 Other Revised 11/08/15 Isis Pharmaceuticals, Inc. - Special Call 11/08/15 Other Revised 11/03/15 Isis Pharmaceuticals, Inc. - Special Call 11/03/15 Other Revised 09/18/15 Isis Pharmaceuticals, Inc. Presents at Morgan Stanley Global Healthcare Conference - New York, Sep-18-2015 01:00 PM 09/18/15 Earnings Revised 08/04/15 Isis Pharmaceuticals, Inc., Q2 2015 Earnings Call, Aug 04, 2015 08/04/15 Other Revised 06/30/15 Isis Pharmaceuticals, Inc. - Shareholder/Analyst Call 06/30/15 Other Revised 06/11/15 Isis Pharmaceuticals, Inc. - Special Call 06/11/15 Other Revised 06/10/15 Isis Pharmaceuticals, Inc. Presents at Goldman Sachs 36th Annual Global Healthcare Conference, Jun-10-2015 02:40 PM 06/10/15 Other Revised 06/04/15 Isis Pharmaceuticals, Inc. - Special Call 06/04/15 Other Revised 05/19/15 Isis Pharmaceuticals, Inc. Presents at UBS Global Healthcare Conference, May-19-2015 01:00 PM 05/19/15 Other Revised 05/12/15 Isis Pharmaceuticals, Inc. Presents at Bank of America Merrill Lynch 2015 Health Care Conference, May-12-2015 09:20 AM 05/12/15 Other Revised 05/07/15 Isis Pharmaceuticals, Inc. Presents at 40th Annual Deutsche Bank Health Care Conference, May-07-2015 12:50 PM 05/07/15 Earnings Revised 05/05/15 Isis Pharmaceuticals, Inc., Q1 2015 Earnings Call, May 05, 2015 05/05/15 Earnings Revised 02/27/15 Isis Pharmaceuticals, Inc., 2014 Earnings Call, Feb 27, 2015 02/27/15 Other Revised 01/12/15 Isis Pharmaceuticals, Inc. Presents at 33rd Annual J.P. Morgan Healthcare Conference, Jan-12-2015 02:30 PM 01/12/15

Other Revised 12/08/14 Isis Pharmaceuticals, Inc. - Special Call 12/08/14 Other Revised 12/01/14 Isis Pharmaceuticals, Inc. Presents at 7th Annual 2014 Deutsche Bank BioFEST, Dec-01-2014 08:40 AM 12/01/14 Other Revised 11/20/14 Isis Pharmaceuticals, Inc. Presents at Goldman Sachs Group 2014 US Emerging / SMID Cap Growth Conference, Nov-20-2014 07:30 AM 11/20/14 Earnings Revised 11/07/14 Isis Pharmaceuticals, Inc., Q3 2014 Earnings Call, Nov 07, 2014 11/07/14 Other Revised 10/10/14 Isis Pharmaceuticals, Inc. - Special Call 10/10/14 Other Revised 09/08/14 Isis Pharmaceuticals, Inc. Presents at 2014 Morgan Stanley Global Healthcare Conference, Sep-08-2014 12:50 PM 09/08/14 Earnings Revised 08/04/14 Isis Pharmaceuticals, Inc., Q2 2014 Earnings Call, Aug 04, 2014 08/04/14 Other Revised 06/16/14 Isis Pharmaceuticals, Inc. - Shareholder/Analyst Call 06/16/14 Other Revised 06/11/14 Isis Pharmaceuticals, Inc. Presents at Goldman Sachs 35th Annual Global Healthcare Conference, Jun-11-2014 08:40 AM 06/11/14 Other Revised 06/10/14 Isis Pharmaceuticals, Inc. - Shareholder/Analyst Call 06/10/14 Other Revised 05/22/14 Isis Pharmaceuticals, Inc. - Special Call 05/22/14 Other Revised 05/21/14 Isis Pharmaceuticals, Inc. Presents at UBS Global Healthcare Conference, May-21-2014 08:00 AM 05/21/14 Other Revised 05/07/14 Isis Pharmaceuticals, Inc. Presents at Deutsche Bank Securities 39th Annual Health Care Conference, May-07-2014 12:50 PM 05/07/14 Earnings Revised 05/06/14 Isis Pharmaceuticals, Inc., Q1 2014 Earnings Call, May 06, 2014 05/06/14 Other Revised 04/29/14 Isis Pharmaceuticals, Inc. - Special Call 04/29/14 Other Revised 03/13/14 Isis Pharmaceuticals, Inc. Presents at Barclays Capital 2014 Global Healthcare Conference, Mar-13-2014 09:00 AM 03/13/14 Earnings Revised 02/28/14 Isis Pharmaceuticals, Inc., Q4 2013 Earnings Call, Feb 28, 2014 02/28/14 Other Revised 02/24/14 Isis Pharmaceuticals, Inc. - Special Call 02/24/14 Other Revised 01/13/14 Isis Pharmaceuticals, Inc. Presents at The JPMorgan 32nd Annual Healthcare Conference, Jan-13-2014 04:30 PM 01/13/14

Other Revised 12/02/13 Isis Pharmaceuticals, Inc. Presents at 2013 Deutsche Bank BioFEST, Dec-02-2013 08:25 AM 12/02/13 Other Revised 11/19/13 Isis Pharmaceuticals, Inc. - Special Call 11/19/13 Earnings Revised 11/05/13 Isis Pharmaceuticals, Inc., Q3 2013 Earnings Call, Nov 05, 2013 11/05/13 Other Revised 09/23/13 Isis Pharmaceuticals, Inc. - Special Call 09/23/13 Other Revised 09/10/13 Isis Pharmaceuticals, Inc. Presents at Morgan Stanley Global Healthcare Conference, Sep-10-2013 02:05 PM 09/10/13 Other Revised 09/09/13 Isis Pharmaceuticals, Inc. - Special Call 09/09/13 Other Revised 09/03/13 Isis Pharmaceuticals, Inc. - Special Call 09/03/13 Earnings Revised 08/06/13 Isis Pharmaceuticals, Inc., Q2 2013 Earnings Call, Aug 06, 2013 08/06/13 Other Revised 06/25/13 Isis Pharmaceuticals, Inc. - Shareholder/Analyst Call 06/25/13 Other Revised 06/24/13 Isis Pharmaceuticals, Inc. - Special Call 06/24/13 Other Revised 06/12/13 Isis Pharmaceuticals, Inc. Presents at Goldman Sachs 34th Annual Global Healthcare Conference, Jun-12-2013 01:20 PM 06/12/13 Other Revised 06/03/13 Isis Pharmaceuticals, Inc. - Special Call 06/03/13 Other Revised 05/30/13 Isis Pharmaceuticals, Inc. Presents at 38th Annual Deutsche Bank Health Care Conference, May-30-2013 08:40 AM 05/30/13 Other Revised 05/20/13 Isis Pharmaceuticals, Inc. Presents at UBS Global Healthcare Conference, May-20-2013 09:00 AM 05/20/13 Other Revised 05/15/13 Isis Pharmaceuticals, Inc. Presents at Merrill Lynch 2013 Health Care Conference, May-15-2013 08:40 AM 05/15/13 Earnings Revised 05/07/13 Isis Pharmaceuticals, Inc., Q1 2013 Earnings Call, May 07, 2013 05/07/13 Other Revised 03/21/13 Isis Pharmaceuticals, Inc. - Special Call 03/21/13 Other Revised 03/13/13 Isis Pharmaceuticals, Inc. Presents at Barclays Global Healthcare Conference, Mar-13-2013 02:00 PM 03/13/13 Earnings Revised 02/28/13 Isis Pharmaceuticals, Inc., 2012 Earnings Call, Feb 28, 2013 02/28/13 Other Revised 01/30/13 Isis Pharmaceuticals, Inc. - Special Call 01/30/13 Other Revised 01/09/13 Isis Pharmaceuticals, Inc. Presents at 31st Annual JPMorgan Healthcare Conference, Jan-09-2013 01:30 PM 01/09/13

Other Revised 12/14/12 Isis Pharmaceuticals, Inc. - Special Call 12/14/12 Other Revised 12/11/12 Isis Pharmaceuticals, Inc. - Special Call 12/11/12 Other Revised 12/07/12 Isis Pharmaceuticals, Inc. - Special Call 12/07/12 Other Revised 11/15/12 Isis Pharmaceuticals, Inc. Presents at Credit Suisse 21st Annual Healthcare Conference, Nov-15-2012 09:00 AM 11/15/12 Other Revised 11/13/12 Isis Pharmaceuticals, Inc. Presents at Lazard Capital Markets, LLC's 9th Annual Healthcare Conference, Nov-13-2012 02:00 PM 11/13/12 Earnings Revised 11/06/12 Isis Pharmaceuticals, Inc., Q3 2012 Earnings Call, Nov 06, 2012 11/06/12 Other Revised 10/18/12 Isis Pharmaceuticals, Inc. - Special Call 10/18/12 Other Revised 09/19/12 Isis Pharmaceuticals, Inc. Presents at UBS Global Life Sciences Conference, Sep-19-2012 01:30 PM 09/19/12 Other Revised 09/11/12 Isis Pharmaceuticals, Inc. Presents at Morgan Stanley Global Healthcare Conference, Sep-11-2012 02:00 PM 09/11/12 Other Revised 08/29/12 Isis Pharmaceuticals, Inc. - Special Call 08/29/12 Earnings Revised 08/06/12 Isis Pharmaceuticals, Inc., Q2 2012 Earnings Call, Aug 06, 2012 08/06/12 Other Revised 06/07/12 Isis Pharmaceuticals, Inc. - Shareholder/Analyst Call 06/07/12 Other Revised 06/05/12 Isis Pharmaceuticals, Inc. Presents at Goldman Sachs 33rd Annual Global Healthcare Conference, Jun-05-2012 01:20 PM 06/05/12 Other Revised 06/01/12 Isis Pharmaceuticals, Inc. - Special Call 06/01/12 Other Revised 05/15/12 Isis Pharmaceuticals, Inc. Presents at BofA Merrill Lynch 2012 Health Care Conference, May-15-2012 02:20 PM 05/15/12 Earnings Revised 05/08/12 Isis Pharmaceuticals, Inc., Q1 2012 Earnings Call, May 08, 2012 05/08/12 Other Revised 05/04/12 Isis Pharmaceuticals, Inc. - Special Call 05/04/12 Other Revised 03/14/12 Isis Pharmaceuticals, Inc. Presents at Barclays Capital 2012 Global Healthcare Conference, Mar-14-2012 03:45 PM 03/14/12 Earnings Revised 02/29/12 Isis Pharmaceuticals, Inc., Q4 2011 Earnings Call, Feb 29, 2012 02/29/12 Other Revised 02/28/12 Isis Pharmaceuticals, Inc. Presents at Citi Global Healthcare Conference 2012, Feb-28-2012 02:00 PM 02/28/12 Other Revised 01/05/12 Isis Pharmaceuticals, Inc. - Special Call 01/05/12

Other Revised 12/15/11 Isis Pharmaceuticals, Inc. - Special Call 12/15/11 Earnings Revised 11/07/11 Isis Pharmaceuticals, Inc., Q3 2011 Earnings Call, Nov 07, 2011 11/07/11 Other Revised 09/19/11 Isis Pharmaceuticals, Inc. Presents at UBS Investment Bank's Global Life Sciences Conference, Sep-19-2011 01:30 PM 09/19/11 Earnings Revised 08/04/11 Isis Pharmaceuticals, Inc., Q2 2011 Earnings Call, Aug 04, 2011 08/04/11 Earnings Revised 05/05/11 Isis Pharmaceuticals, Inc., Q1 2011 Earnings Call, May 05, 2011 05/05/11 Earnings Revised 02/28/11 Isis Pharmaceuticals, Inc., 2010 Earnings Call, Feb 28, 2011 02/28/11

Earnings Revised 11/04/10 Isis Pharmaceuticals, Inc., Q3 2010 Earnings Call, Nov 04, 2010 11/04/10 Earnings Revised 08/09/10 Isis Pharmaceuticals, Inc., Q2 2010 Earnings Call, Aug-09-2010 08/09/10 Earnings Revised 05/06/10 Isis Pharmaceuticals, Inc., Q1 2010 Earnings Call, May-06-2010 05/06/10 Earnings Revised 03/01/10 Isis Pharmaceuticals, Inc., 2009 Earnings Call, Mar 01, 2010 03/01/10

Earnings Revised 11/05/09 Isis Pharmaceuticals, Inc., Q3 2009 Earnings Call, Nov-05-2009 11/05/09 Earnings Revised 08/06/09 Isis Pharmaceuticals, Inc., Q2 2009 Earnings Call, Aug-06-2009 08/06/09 Earnings Revised 02/25/09 Isis Pharmaceuticals, Inc., 2008 Earnings Call, Feb-25-2009 02/25/09

Earnings Revised 11/10/08 Isis Pharmaceuticals, Inc., Q3 2008 Earnings Call, Nov-10-2008 11/10/08 Earnings Revised 08/07/08 Isis Pharmaceuticals, Inc., Q2 2008 Earnings Call, Aug-07-2008 08/07/08 Earnings Revised 05/12/08 Isis Pharmaceuticals, Inc., Q1 2008 Earnings Call, May-12-2008 05/12/08

Earnings Revised 11/08/07 Isis Pharmaceuticals, Inc., Q3 2007 Earnings Call, Nov-08-2007 11/08/07