from SC 13G/A
1 page
<page> Exhibit 1 Agreement Regarding Joint Filing the Undersigned, Biotechnology Value Fund, L.P., a Delaware Limited Partnership, Biotechnology Value Fund II, L.P., a Delaware Limited Partnership, Bvf Partners L.P., a Delaware Limited Partnership, and Bvf Inc., a Delaware Corporation, Hereby Agree and Acknowledge That the Information Required by the Amendment to Schedule 13g, to Which This Agreement Is Attached as an Exhibit, Is Filed on Behalf of Each of Them. the Undersigned Further Agree That Any Further Amendments or Supplements Thereto Shall Also Be Filed on Behalf of Each of Them. Dated: November 10, 2000 Biotechnology Value Fund, L.P. By: Bvf Partners L.P., Its General Partner By: Bvf Inc., Its General Partner By: Mark N. Lampert /S/ Mark N. Lampert President Biotechnology Value Fund II, L.P. By: Bvf Partners L.P., Its General Partner By: Bvf Inc., Its General Partner By: Mark N. Lampert /S/ Mark N. Lampert President Bvf Partners L.P. By: Bvf Inc., Its General Partner By: Mark N. Lampert /S/ Mark N. Lampert President Bvf Inc. By: Mark N. Lampert /S/ Mark N. Lampert President
