Shire Plc Watch

from 10-K 13 pages Executive Employment Agreement

from 10-K 4 pages Annual Incentive Plan

from 10-K 4 pages Shire International Gmbh Zählerweg 10 Ch-6300, Zug Switzerland Tel: +41 (0) 41 288 40 00 Fax: +41 (0) 41 288 40 05 Shire.com 19 November 2017 Confidential Buy-Out Awards

from 8-K 27 pages Contingent Value Rights Agreement by and Between Shire Plc and American Stock Transfer & Trust Company, LLC as Rights Agent Dated as of January 22, 2015

from 425 149 pages Shire Plc as the Company Barclays Bank PLC and Morgan Stanley Bank International Limited as Mandated Lead Arrangers and Bookrunners With Barclays Bank PLC as Agent US$18,000,000,000 Bridge Facilities Agreement Dated 11 January 2016 Slaughter and May One Bunhill Row London Ec1y 8yy (Mjxt/Azn/Mrg/Aezw) 533125364 Contents

from 8-K 149 pages Shire Plc as the Company Barclays Bank PLC and Morgan Stanley Bank International Limited as Mandated Lead Arrangers and Bookrunners With Barclays Bank PLC as Agent US$18,000,000,000 Bridge Facilities Agreement Dated 11 January 2016 Slaughter and May One Bunhill Row London Ec1y 8yy (Mjxt/Azn/Mrg/Aezw) 533125364 Contents

from 8-K 21 pages This Letter Agreement Is Entered Into on the Date First Set Forth Above by and Among Shire Plc, a Company Incorporated in Jersey ("Parent"), Baxalta Incorporated, a Delaware Corporation ("Baxalta"), and Baxter International Inc., a Delaware Corporation ("Baxter") (This "Letter Agreement"). Reference Is Made to That Certain Tax Matters Agreement, Dated as of June 30, 2015, by and Among Baxter, by and on Behalf of Itself and Each Affiliate of Baxter, and Baxalta, by and on Behalf of Itself and Each Affiliate of Baxalta (The "Tax Matters Agreement") and That Certain Shareholder's and Registration Rights Agreement, Dated as of June 30, 2015, by and Between Baxter and Baxalta (The "Registration Rights Agreement"). Pursuant to a Merger Agreement to Be Entered Into Among Parent, Beartracks, Inc., a Delaware Corporation, and Baxalta (The "Merger Agreement"), Parent Will, Directly or Indirectly, Acquire All of the Outstanding Shares of Baxalta Common Stock (The "Merger"), Subject to the Satisfaction of Certain Closing Conditions as Described in the Merger Agreement. Capitalized Terms Used but Not Defined Herein Have the Meanings Given to Them in the Tax Matters Agreement. Parent, Baxalta and Baxter Hereby Agree as Follows: 1. Support of Baxter; Waiver of Appraisal Rights

from 425 21 pages This Letter Agreement Is Entered Into on the Date First Set Forth Above by and Among Shire Plc, a Company Incorporated in Jersey ("Parent"), Baxalta Incorporated, a Delaware Corporation ("Baxalta"), and Baxter International Inc., a Delaware Corporation ("Baxter") (This "Letter Agreement"). Reference Is Made to That Certain Tax Matters Agreement, Dated as of June 30, 2015, by and Among Baxter, by and on Behalf of Itself and Each Affiliate of Baxter, and Baxalta, by and on Behalf of Itself and Each Affiliate of Baxalta (The "Tax Matters Agreement") and That Certain Shareholder's and Registration Rights Agreement, Dated as of June 30, 2015, by and Between Baxter and Baxalta (The "Registration Rights Agreement"). Pursuant to a Merger Agreement to Be Entered Into Among Parent, Beartracks, Inc., a Delaware Corporation, and Baxalta (The "Merger Agreement"), Parent Will, Directly or Indirectly, Acquire All of the Outstanding Shares of Baxalta Common Stock (The "Merger"), Subject to the Satisfaction of Certain Closing Conditions as Described in the Merger Agreement. Capitalized Terms Used but Not Defined Herein Have the Meanings Given to Them in the Tax Matters Agreement. Parent, Baxalta and Baxter Hereby Agree as Follows: 1. Support of Baxter; Waiver of Appraisal Rights

from 8-K 2 pages Shire PLC - Consent Request Approval Notice

from 8-K 189 pages Shire Plc as the Company Morgan Stanley Bank International Limited and Deutsche Bank AG, London Branch as Mandated Lead Arrangers and Bookrunners With Deutsche Bank AG, London Branch as Agent US$ 5,600,000,000 Term Facilities Agreement Dated November 2015 Slaughter and May One Bunhill Row London Ec1y 8yy (Azn/Dhc) 532026286 Contents

from 8-K 26 pages Contingent Value Rights Agreement by and Between Shire Plc and American Stock Transfer & Trust Company, LLC as Rights Agent Dated as of [·], 2015

from 10-Q 31 pages Executive Employment Agreement

from 8-K 175 pages Shire Plc as the Company Citigroup Global Markets Limited as Mandated Lead Arranger and Bookrunner With Citibank International Limited as Agent US$ 850,000,000 Term Facility Agreement Dated 11 January 2015 Slaughter and May One Bunhill Row London Ec1y 8yy (Mjd) Contents

from SC TO-C 175 pages Shire PLC as the Company Citigroup Global Markets Limited as Mandated Lead Arranger and Bookrunner With Citibank International Limited as Agent US$ 850,000,000 Term Facility Agreement Dated 11 January 2015 Slaughter and May One Bunhill Row London Ec1y 8yy (Mjd) Contents

from 8-K ~5 pages Shire PLC - US$2,600,000,000 Term Facilities Agreement Dated 11 November 2013

from 8-K ~5 pages Shire PLC - US$ 2,600,000,000 Term Facilities Agreement Dated 11 November 2013

from 8-K ~1 page Shire PLC - US$2,600,000,000 Term Facilities Agreement Dated 11 November 2013

from SC TO-C 172 pages Shire Plc as the Company Morgan Stanley Bank International Limited as Mandated Lead Arranger and Bookrunner With Morgan Stanley Bank International Limited as Agent US$ 2,600,000,000 Term Facilities Agreement Dated 11 November 2013 Slaughter and May One Bunhill Row London Ec1y 8yy (Rel/Apxk) 516285245 Contents

from 8-K 172 pages Shire Plc as the Company Morgan Stanley Bank International Limited as Mandated Lead Arranger and Bookrunner With Morgan Stanley Bank International Limited as Agent US$ 2,600,000,000 Term Facilities Agreement Dated 11 November 2013 Slaughter and May One Bunhill Row London Ec1y 8yy (Rel/Apxk) 516285245 Contents

from 10-K 32 pages Confidential: Privileged and Confidential Executive Employment Agreement